3D-Bioplotter (EnvisionTEC, Germany)

bioplotter 2The 3D-Bioplotter™ System (EnvisionTEC, Germany) is a suitable Rapid Prototyping tool for processing a great variety of biomaterials within the process of Computer Aided Tissue Engineering from scaffolds 3D CAD model to the physical 3D scaffold with a designed and defined outer form and an open inner structure. Tissue Engineering and Controlled Drug Release require 3D scaffolds with well defined external and internal structures.

The 3D-Bioplotter™ has the capacity of fabricating scaffolds using the widest range of materials of any singular Rapid Prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. The 3D-Bioplotter™ is specially designed for work in sterile environments in a laminar flowbox, a requirement of Biofabrication, for example when using alginate cell suspensions for scaffold construction.

Bioscaffolder (SYS&ENG, Germany)


System-Solution for manufacturing of customised 3D tissue scaffolds / patient specific implants with defined external shape and internal architecture (three dimensional distribution of interconnective porosity and material) from multiple biomaterials based on 3D-dispensing.

In conjunction with the method of rapid prototyping – using specialized computer software – we can design any shape we need.




Plastometer – Instron


Instron’s CEAST Melt Flow Multiple Weight Tester is a major development in melt flow testing. The output results include the shear sensitivity (or flow rate ratio), one of the first data for wider rheological investigation, and the first low shear rate points of the rheological curve of the sample.





Thermogravimetric Analyzer – modular TGA Q5000 FTIR


Thermogravimetric Analyzer (TGA) is a thermal weight-change analysis instrument, used in conjunction with a controller computer and associated software to make up a thermal analysis system.

The Thermogravimetric Analyzer measures the amount and rate of weight change in a material, either as a function of increasing temperature, or isothermally as a function of time, in a controlled atmosphere. It can be used to characterize any material that exhibits a weight change and to detect phase changes due to decomposition, oxidation, or dehydration.




[spoiler]TGA is working in conjunction with FTIR spectrometer. Fourier transform infrared spectroscopy (FTIR) is a technique which is used to obtain an infrared spectrum of absorption, emission, photoconductivity or Raman scattering of a solid, liquid or gas. An FTIR spectrometer simultaneously collects spectral data in a wide spectral range.


Zamak Double-Screw Extruder


Products of the plastics extruder are extruded in a continuous manner. The extruder is a simplified nutshell plasticizing unit with temperature control system (heaters, fans, sensors) and transmission.


Our extruder is “double-screw” kind:



Contact Angle System OCA

goniometr ocs

With the help of goniometer contact angles of different solvents on solid surfaces can be analyzed. Surface tensions liquids and surface free energies of surfaces. All solid surfaces can be measured and polymer melts. Contact angles can be applied to calculate surface free energies of solids. Determination of drop contours can be applied to determine the surface tension of liquids at varied temperatures. The instrument permits online measuring and film recording at room temperature and up to 350°C, enabling measurements on solids as well as polymer melts.




Differential Scanning Calorimeter Q2000


Differential Scanning Calorimeters (DSC) measures temperatures and heat flows associated with thermal transitions in a material. Common usage includes investigation, selection, comparison and end-use performance evaluation of materials in research, quality control and production applications. Properties measured by TA Instruments’ DSC techniques include glass transitions, “cold” crystallization, phase changes, melting, crystallization, product stability, cure / cure kinetics, and oxidative stability.





More info:

Modular Gel Chromatograph

Modular Gel Chromatograph Agilent 1200 series (degasser, pump, autosampler, thermostat and concentration detector) combined with three-angle laser light scattering detector MiniDAWN Treos and viscosity detector ViscoStar (both Wyatt Technology Company).





Dynamic Mechanical Analysis Q800

q800 dynamic mechanical analysisFrom the producer’s website:

The Q800 is the world’s best-selling DMA, for very good reason. It utilizes state-of-the-art, non-contact, linear drive technology to provide precise control of stress, and air bearings for low friction support. Strain is measured using optical encoder technology that provides unmatched sensitivity and resolution. With its unique design, the Q800 easily outperforms competitive instruments and is ideal for high-stiffness applications, including composites.


  • Maximum Force: 18 N
  • Minimum Force: 0.0001 N
  • Force Resolution: 0.00001 N
  • Strain Resolution: 1 nanometer
  • Modulus Range: 10^3 to 3×10^12 Pa
  • Modulus Precision: ± 1%
  • Tan δ Sensitivity: 0.0001
  • Tan δ Resolution: 0.00001
  • Frequency Range: 0.01 to 200 Hz
  • Dynamic Sample Deformation Range: ± 0.5 to 10 000 μm
  • Temperature Range: -150 to 600°C
  • Heating Rate: 0.1 to 20°C/min
  • Cooling Rate: 0.1 to 10°C/min
  • Isothermal Stability: ± 0.1°C
  • Time/Temperature Superposition: Yes
  • RH Control: Optional

 More info:


ElectroForce 5100 BioDynamic Test Instruments


Overview ElectroForce® BioDynamic® test instruments provide accurate characterization of biomaterials and biological specimens within a sterile cell culture media environment.

The instruments can be used for the evaluation of a variety of speciments, including biomaterials, acellular and cell-seeded scaffolds, native tissue samples and tissue-engineered constructs.












Ultramicrotome Leica EM UC7


Information from the producer’s website:

The Ultramicrotome Leica EM UC7 provides easy preparation of semi- and ultrathin sections as well as perfect, smooth surfaces of biological and industrial samples for TEM, SEM, AFM and LM examination. New Standard in Ultramicrotomy Combining ergonomic design and innovative technology the Ultramicrotome Leica EM UC7 sets new standards in Ultramicrotomy. It offers a range of outstanding features and benefits of use for the ultramicrotomist, whether highly skilled or absolute beginners.

Working in a set withLeica EM SCD500 and Leica EM TXP.


High vacuum sputter coater for highest resolution FE-SEM analysis Leica EM SCD500


The Leica EM SCD500 is a versatile high vacuum film deposition system designed to produce very thin, fine-grained metal films and conductive carbon coatings for highest resolution FE-SEM analysis.







Target Surfacing System Leica EM TXP


The Leica EM TXP is a target preparation device for milling, sawing, grinding, and polishing samples prior to examination by SEM, TEM, and LM techniques.







Scanning Electron Microscope HITACHI SU 8000

Scanning electron microscope HITACHI SU 8000 is a device designed to study the internal structure of biomaterials and their surface morphology of micro-and nanoscale.

The device structure allows to obtain images with a resolution of 1 nm at a voltage of 15 kV or 1.4 nm at a voltage of 1 kV.,

Use as a source of cold electron field emission and patented by Hitachi ExB filtering system allows imaging surface of the nonconductive samples. Device is equipped with a range of detectors, which allow to obtain various types of contrast, which in turn allows you to get complete information about the structure of the material.


 X-Ray micro-­CT SkyScan 1174 (portable)


X-Ray micro - CT SkyScan 1174The SkyScan is a revolutionary laboratory nano-CT scanner with spatial resolution in the range of hundreds of nanometers. This spatial resolution in volume terms is equal to or better than that of synchrotron tomography. For the first time true sub-micron tomographic imaging is available in a laboratory instrument. The 2011 nano-CT employs an open-type x-ray source with a LaB6 cathode which achieves the unprecedented focal spot size of <400nm.

At this small spot size, small-angle scattering enhances object details down to 150-200nm. A sophisticated object manipulator allows object positioning and rotation with an accuracy of better than 100nm. The x-ray detector is based on an intensified CCD with single photon sensitivity. The object is scanned under normal environmental conditions, without any coating, vacuum treatment or other preparation.



X-Ray micro-CT SkyScan 1172

X-Ray micro-CT SkyScan 1172From the producer’s website:

The innovative flexible geometry of the SkyScan 1172 scanner is particularly advantageous over intermediate resolution levels, where scans are several times faster (to obtain the same or better image quality) compared to micro-CT systems with a fixed source-detector design. The new large format cooled x-ray digital camera achieves high spatial resolution without compromising sample size. Fast scan and reconstruction throughput is supported by a computer cluster option, which reconstructs scan datasets in less time than the scan duration in most cases, using several PCs in parallel. Cross section images are generated in a wide range of formats up to 8k x 8k pixels. The full range of SkyScan software for 2D / 3D quantitative analysis and for realistic 3D visualization supplied with all scanners.


  • X-ray source – 20-100kV, 10W, <5µm spot size or 20-80kV, 8W, <8µm spot size
  • X-ray detector – 11Mp, 12-bit cooled CCD fiber-optically coupled to scintillator
  • Maximum object size – 27mm in diameter (single scan) or 50mm in diameter (offset scan)
  • Detail detectability – 0.5µm at highest resolution
  • Reconstruction – single PC or cluster volumetric reconstruction
  • Optional stages – micropositioning, cooling, compression / tension
  • Radiation safety – <1µSv / h at any point on the instrument surface

More info:

X-Ray nanotomograph SkyScan 2011 

X-Ray nanotomograph SkyScan 2011The SkyScan 2011 is a revolutionary laboratory nano-CT scanner with spatial resolution in the range of hundreds of nanometers. This spatial resolution in volume terms is equal to or better than that of synchrotron tomography. For the first time true sub-micron tomographic imaging is available in a laboratory instrument. The 2011 nano-CT employs an open-type x-ray source with a LaB6 cathode which achieves the unprecedented focal spot size of <400nm. At this small spot size, small-angle scattering enhances object details down to 150-200nm. A sophisticated object manipulator allows object positioning and rotation with an accuracy of better than 100nm. The x-ray detector is based on an intensified CCD with single photon sensitivity. The object is scanned under normal environmental conditions, without any coating, vacuum treatment or other preparation.The full range of SkyScan software is supplied, including fast volumetric reconstruction, software for 2D / 3D quantitative analysis and for realistic 3D visualization.


  • X-ray source – open (pumped) type 20-80kV, LaB6
  • X-ray detector – intensified 1280×1024 pixels, 12bit CCD with FireWire output     
  • Positioning accuracy – <100nm for rotation during scanning, <200nm overall stability     
  • Spatial resolution – <150nm pixel size (isotropic), 400nm low-contrast (10%MTF)     
  • Object size – 0.2-1mm for max. resolution, 11mm max.diameter (9µm pixels)     
  • Typical scanning time – 15-90min for entire object volume (1280x1280x900 pixels )     
  • Radiation safety – <1µSv / h at any point on the instrument surface

more info:

Scanning Probe Microscope – Bruker/Veeco MultiMode AFM NanoScope 8 with Peak Force QNM (Quantitative Nanomechanical Mapping)


Information from the producent’s site:

Scanning Probe Microscope – Multimode AFM Nanoscope 8

(Veeco/Brucker) is a compact, highly-flexible system offering a complete range of techniques for surface characterization of properties such as topography, elasticity, friction, adhesion, and magnetic/electrical fields. The electrochemistry option in both AFM and STM modes delivers atomic- and molecular-resolution imaging of electrode surfaces in solution under electrochemical control. PicoForce module brings unprecedented accuracy and flexibility to single-molecule force spectroscopy for molecular biology and materials research.


From Wikipedia:

Atomic force microscopy (AFM) or scanning force microscopy (SFM) is a very high-resolution type of scanning probe microscopy, with demonstrated resolution on the order of fractions of a nanometer, more than 1000 times better than the optical diffraction limit.

[spoiler]The AFM is one of the foremost tools for imaging, measuring, and manipulating matter at the nanoscale. The information is gathered by “feeling” the surface with a mechanical probe. Piezoelectric elements that facilitate tiny but accurate and precise movements on (electronic) command enable the very precise scanning. In some variations, electric potentials can also be scanned using conducting cantilevers. In newer more advanced versions, currents can even be passed through the tip to probe the electrical conductivity or transport of the underlying surface, but this is much more challenging with very few research groups reporting consistent data.

  • Contact mode – In the static mode operation, the static tip deflection is used as a feedback signal. Because the measurement of a static signal is prone to noise and drift, low stiffness cantilevers are used to boost the deflection signal. However, close to the surface of the sample, attractive forces can be quite strong, causing the tip to “snap-in” to the surface. Thus static mode AFM is almost always done in contact where the overall force is repulsive. Consequently, this technique is typically called “contact mode”. In contact mode, the force between the tip and the surface is kept constant during scanning by maintaining a constant deflection.
  • Non-contact mode AFM – In this mode, the tip of the cantilever does not contact the sample surface. The cantilever is instead oscillated at a frequency slightly above its resonant frequency where the amplitude of oscillation is typically a few nanometers (<10 nm). The van der Waals forces, which are strongest from 1 nm to 10 nm above the surface, or any other long range force which extends above the surface acts to decrease the resonance frequency of the cantilever. This decrease in resonant frequency combined with the feedback loop system maintains a constant oscillation amplitude or frequency by adjusting the average tip-to-sample distance. Measuring the tip-to-sample distance at each (x,y) data point allows the scanning software to construct a topographic image of the sample surface.
  • Tapping mode – In ambient conditions, most samples develop a liquid meniscus layer. Because of this, keeping the probe tip close enough to the sample for short-range forces to become detectable while preventing the tip from sticking to the surface presents a major problem for non-contact dynamic mode in ambient conditions. Dynamic contact mode (also called intermittent contact or tapping mode) was developed to bypass this problem. This method of “tapping” lessens the damage done to the surface and the tip compared to the amount done in contact mode. Tapping mode is gentle enough even for the visualization of supported lipid bilayers or adsorbed single polymer molecules (for instance, 0.4 nm thick chains of synthetic polyelectrolytes) under liquid medium. With proper scanning parameters, the conformation of single molecules can remain unchanged for hours


Scanning Probe Microscope – MFP-3D-Bio Atomic Force Microscope

afm bio1MFP-3D-Bio Atomic Force Microscope from Asylum Research Oxford Instruments is designed specifically for biological and biomaterials applications.

The MFP-3D-Bio AFM is an extremely versatile scanning probe microscope on an Olympus IX-73 inverted optical microscope platform. The 3D closed-loop scanner has a 90 µm range and 0.5 nm resolution in the X and Y directions, and a 40 µm range and 0.3 nm resolution in the Z direction.

In addition to basic contact and tapping/semi-contact (AC) mode topographic scanning, unique or superior capabilities of the MFP-3D it allows the precise measurements of sample mechanicals properties including e.g.: Elastic Modulus, Deformation, Adhesion Force.

The AFM is equipped with acoustic enclosure, active vibration isolation and Petri dish heater. Microscope can work in air and liquid environments.

For more info:


schemat afm bioLiving_cell_PBS_solution v1[/spoiler]

Phenom proX desktop scanning electron microscope

Phenom proX desktop SEMUltimate all-in-one imaging and X-ray analysis system. With the Phenom proX desktop SEM, sample structures can be physically examined and their elemental composition determined.

Viewing three-dimensional images of microscopic structures only solves half the problem when analyzing samples. It is often necessary to collect more than optical data to be able to identify the different elements in a specimen. This is accomplished in the Phenom proX with a fully integrated and specifically designed EDS detector.

EDS is a technique that analyzes X-rays generated by the bombardment of the sample by an electron beam. EDS elemental analysis is fully embedded into the Phenom proX system. X-ray detector and control software are combined in one package.


Key Specifications

Magnification range 20 – 45,000x
Element detection range: C – Am
Long-life high-brightness source (CeB6)
Multi-high-voltage range: 5 – 15kV
Electron beam current selection for tuning imaging settings or high throughput analysis

(from the producer’s website)[/spoiler]

Confocal Microscope – Leica TCS SP8

konfokal clearFrom the producer’s website:

Leica TCS SP8 has been designed for confocal microscopy with optimal photon efficiency and high speed. All optical components are matched towards preserving fluorescence photons for image contrast and to improve cell viability in live cell imaging. Backing up this sensitive detection are a high speed scanning system with up to 428 frames per second, large field of view of field number 22 and accelerated Z-stacking by a novel mode for the SuperZ galvanometer called Galvoflow. This suits the instrument for the most demanding samples, highest speed while offering full confocal resolution.

The Leica TCS SP8 delivers publication ready images out of the box along with comprehensive upgrade options.

Our Confocal Microscope works coupled with Raman Microscope.


Raman Microscope – Renishaw

raman i konfoIt is equipped with two detectors, two diffraction gratings (1800 lines/mm, 1200 lines/mm), a set for polarization analysis in a VIS/NIR range. Spectral resolution limit of <1 cm-1 in the visible region. The device allows the measurement of Raman spectra in the range of 100 to 4000 cm-1. Spectrometer’s Rayleigh filter allows to perform the Raman study of 100 cm-1 at a wavelength of 514nm / 633nm, 100 cm-1 at a wavelength of 785nm. Kit works in transmission and reflection. It’s equipped with three excitation lasers (514nm Ar laser, He-Ne laser and a 633nm diode laser HPNIR). Raman spectrometer is capable of imaging/mapping using the Raman method: point, line, and fast imaging of a streamline or linescan.

Our Raman Microscope works coupled with Confocal Microscope


[spoiler]From the producer’s website:

inVia Raman microscopes are high-sensitivity systems with integrated research grade microscopes, enabling high resolution confocal measurements.

inVia Raman microscopes support multiple lasers, with automatic software switching of excitation wavelength.

With a comprehensive range of Rayleigh filter options, and motorised switching, it’s easy to configure the system to suit your analytical needs.


ReaLizer SLM 50

Realizer SLMWith the SLM 50, Realizer delivers the globally first SLM desktop machine for manufacturing components made of metal. The desktop device has been designed for the manufacturing of components with a diameter of up to 70 mm and a height of up to 40 mm. Realizer, in its function as technology leader, can fall back on many years of experience with this process in the development of SLM machines.

For Selective Laser Melting (SLM), the work piece is directly created in layers, based on 3D data. To effect this, metal powder (e.g. stainless steel, tool steel, cobalt chrome, or gold) is applied in thin layers and melted on at the predetermined locations using a powerful fibre laser. Following each melting process, the work platform is lowered so that the next layer can be applied. This way, precise and complex functional components are created which not only feature the same material properties as conventionally produced components but can also be processed the same way.

FLUOstar Omega – fluorymeter, luminometer, spectrometer

FLUOstarOmegaFrom the producer’s website:

The Best Drug Discovery Product 2010, FLUOstar Omega, is a multi-mode microplate reader featuring BMG LABTECH’s uniqueTandem Technology. It utilizes high speed UV/Vis spectrometer based absorbance and ultra sensitive filter-based detection in all detection modes such as:

  • UV/Vis Absorbance – measurement of complete spectra or individual wavelengths
  • Fluorescence Intensity – including FRET
  • Time-Resolved Fluorescence – including DELFIA®
  • TR-FRET – including HTRF® and LanthaScreenTM
  • AlphaScreen® / AlphaLISA®
  • High-Performance Luminescence (flash and glow) – including BRET


Advanced Assay Technology Package for the FLUOstar Omega:
BMG LABTECH engineers have designed a specialized measurement mode and optical system to provide the Omega multimode microplate readers with AlphaScreen® / AlphaLISA® performance that rivals any HTS microplate reader. For the first time, experience fantastic AlphaScreen® / AlphaLISA® performance on a mid-range multi-mode microplate reader.

Furthermore, Advanced Performance TRF is part of the Omega’s optional Advanced Assay Technology Package. It utilizes an optional high-end TRF optical reading head that incorporates an assay specific dichroic mirror. Combined with the high intensity xenon flash lamp, assay optimized filters and adjustable gain, the Omega high-end TRF reading head allows the Omega to outperform any microplate reader in the mid-range market. [/spoiler]

Verticalal Laminar Flow ESCO

incubatorFrom the producer’s website:

Esco Airstream Vertical Laminar Flow Clean Benches offer proven protection for your samples and processes where operator protection is not required. Vertical laminar flow offers certain tangible advantages over horizontal flow clean benches (which may be the convention in some parts of the world), such as lower energy consumption (40% of conventional systems) levels through the use of exclusive motorized impeller technology and less airflow turbulence (especially when large objects are used in the work zone). In fact, the negative pressure filter mounting system employed on these models is widely recognized to be superior to that of conventional horizontal flow clean benches.

Key Benefits:
  • ISO Class 4 workzone
  • Airflow monitoring
  • Energy saving



Incubator ESCO

SONY DSCFrom the producer’s website:

Esco CelCulture CO2 incubators are widely used in scientific research to grow and maintain cell cultures. Typical fields of application include tissue engineering, in vitro fertilization, neuroscience, cancer research, stem cell research, regenerative medicine,  and other mammalian cell research.


Sleek, reliable and intuitive, Esco CelCulture CO2 incubators provide all-rounded sample protection that brings your scientific dreams one step closer to reality.




Key Benefits:
  • ULPA filtration system
  • 90oC moist heat decontamination cycle, validated by HPA UK
  • Precise temperature and gas control



nanonDevice for production of the scaffolds by electrospinning solution. Allows the production of polymeric and composite nanofibers with diameters ranging from a few nanometers to several thousands, directly from a polymer solutions, using an electric field.

The device allows you to control the process parameters and environmental conditions, which ensures stability and repeatability of the carried out experiments.

See also producer’s webite.









TC-3 load bioreactor system

ebers tc3The TC-3 Bioreactor has been designed as a simple, easy-to-use system suitable to create cell culture experimental set-ups accounting for user-defined mechanical loading profiles. The needs of researchers who would like to culture cells under mechanical stimuli have been accounted for in the design of the TC-3. It combines the features of a traditional testing machine with the particular demands of cell culture, with special emphasis on the sterilization of the parts which are going to contact the culture medium, the easy assembling, the sample inspection by microscopy techniques and the straightforward sample manipulation.

The TC-3 permits to work with:

  •     Horizontally and vertically arranged multiple samples.
  •     Immersed and air-liquid interface setups.
  •     Sheet-shaped, rod-shaped and cylinder-shaped substrates.
  •     Tension and compression axial loading.
  •     Simultaneous flow and deformation conditions.
  •     Hydrostatic pressure conditions.

See more at: producer’s webite.